The sputum extracellular DNA (eDNA) level has been correlated with expressions of IL-8, IL-1β, and NLRP3 [93], and Lachowicz-Scroggins et al. found that high extracellular DNA (eDNA) in sputum was associated with poor asthma control, mucus hypersecretion, and oral steroid use in patients with asthma [94]. This evidence concerns the gene NLRP3 and asthma.