It may even be used to guide therapy in patients without known cardiovascular disease, as when a cut-off of NT-proBNP > 125 pg/mL was used in high-risk patients with type 2 diabetes mellitus without a known history of cardiovascular disease to decide to intensify anti-hypertensive treatments [7], it resulted in a reduction in the rate of hospitalisation/death due to cardiac disease by 65%. Here, NPPB is linked to diabetes mellitus.