NPPB and cardiovascular disorder: NT-proBNP shows superior prognostic performance even when compared to risk stratification models [13], being more significantly associated with cardiovascular disease death/all-cause death than the ESC/EASD risk model for both outcomes (C-index: CVD death 0.8 vs. 0.53, all-cause death 0.73 vs. 0.52), with NT-proBNP > 125 pg/mL having a 7.2/3.1-fold risk for cardiovascular disease/all-cause death at 10 years.