The SACS gene may be another candidate molecule for AD diagnosis because of its involvement in mitochondrial dysfunction, which is part of the pathophysiology of AD, and three genes JMY, ZNF525, and COBLL1, which are involved in the generation of autophagosomes, transcription regulation glucose consumption, and cadherin/actin binding linked to lower serum insulin levels, respectively, could also be useful in AD diagnosis. The gene discussed is COBLL1; the disease is Alzheimer disease.