Pathological hallmarks of AD are neuritic plaques and neurofibrillary tangles related to the accumulation of the amyloid-β (Aβ) peptide in brain tissue and to cytoskeletal abnormalities that are caused by the accumulation of hyperphosphorylated microtubule-associated protein tau in neurons, respectively [5,20,21]. Here, MAPT is linked to Alzheimer disease.