ILD-IIM patients commonly experience no or mild myalgia, and when present it is often associated with autoantibody positivity, but not with increased levels of muscle enzymes, such as creatine phosphokinase (CPK), aspartate transaminase (AST), lactic dehydrogenase (LDH) or myoglobin [5]. Here, PIK3C2A is linked to acquired idiopathic inflammatory myopathy.