HLA-G and neoplasm: This way, HLA-Gacq+ CD4+ T cells, HLA-Gacq+ CD8+ T cells, HLA-Gacq+ NK cells, and HLA-Gacq+ CD14+ monocytes with immunosuppressive and regulatory activity are formed, further amplifying the tolerogenic effects of HLA-G in tumor immune escape which leads to immune evasion, therapy resistance, disease progression and poor clinical outcomes [43].