Both novel aggressive subtypes roughly doubled the number of DLBCL tumors that could be classified as HGBL-DH/TH-BCL2 based on FISH alone, with DHITsig further demonstrating that at least 19% of HGBL-DH/TH-BCL2 were cryptic to FISH [39]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.