According to Scott et al. [48], the best method for detecting all high-grade B-cell lymphomas with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) among tumors with DLBCL morphology is to screen all DLBCLs for MYC rearrangements. This evidence concerns the gene BCL6 and B-cell non-Hodgkin lymphoma.