Compared to the overall HNSCC prevalence, which is different for male and females, the authors identified a similar 45% pooled prevalence of HPV-driven OPSCC, for both genders, and they also suggested that double p16/HPV-DNA/RNA testing is the optimal method in regard to specificity and prognostic accuracy [11]. Here, CDKN2A is linked to head and neck squamous cell carcinoma.