CRP and calcinosis: Compared to ACA lSSc patients, ACA dSSc patients were more severe as they more frequently had skin sclerosis, as evaluated by mRSS (26 [17–30] vs. 2 [7–25]; p < 0.01), calcinosis (58% vs. 20%; p < 0.05) gastrointestinal tract involvement (92% vs. 58%; p < 0.05), heart involvement (3 (25%) vs. 4 (4%); p < 0.05), muscle involvement (4 (33%) vs. 4 (8%); p < 0.05), inflammatory syndrome (CRP > 5 mg/l) (9 (75%) vs. 14 (5%); p < 0.001), and more frequently received immunosuppressants (5 (42%) vs. 5 (5%); p < 0.01).