SCCA1 and SCCA2 are upregulated by oncogenic Ras via MAPK and the ETS transcription factor PEA3 [85], which can lead to inhibition of protein turnover and an unfolded protein response and is essential for Ras-mediated NF-κB activation, cytokine production, and tumor growth [85,86]. Here, SERPINB3 is linked to neoplasm.