High EPHA2 IRS was correlated with increased tumor vertical thickness (Mann–Whitney U test, p = 0.03, Figure 2), the presence of intrascleral involvement (Fischer’s exact test, p = 0.05) and the presence of metastatic disease (Fischer’s exact test, p = 0.09), the latter correlation, however, being of borderline significance. The gene discussed is EPHA2; the disease is metastatic neoplasm.