The efficiency of the vitamin c treatment in inhibiting leukemic colony formation might also depend on its previously reported ability to restore TET2 function, which drives DNA hypomethylation, by enhancing 5 hmC formations and thereby suppressing leukemic colony formation and the leukemic progression of primary human leukemia patient-derived xenografts (PDXs) [20,60]. The gene discussed is TET2; the disease is leukemia.