Three AML cell lines were used as metabolic models for the AMLs: OCI-AML2 (carrying the DNMT3A R635W mutation), OCI-AML3 (carrying the NPM1 gene mutation type A and the DNMT3A R882C mutation) and MV4-11 (carrying the FLT3-ITD mutation and MLL/AF4 translocation). This evidence concerns the gene DNMT3A and acute myeloid leukemia.