GPX1 and acute myeloid leukemia: Moreover, GPX1 may be involved in AML immunosuppression for its positive correlations with immunosuppressive cells (e.g., myeloid-derived suppressor cells and regulatory T cells), immune inhibitory checkpoint-mediated pathways (TIM3/Galectin-9 and SIRPα/CD47 pathways), and negative correlations with low fraction levels of CD4+ and CD8+ effector T cells [92].