HPV16-positive LDS SCCs harbor a molecular profile resembling other HPV16-positive carcinomas with p16 expression, wildtype status of TP53, frequent pathogenic variants in PIK3CA and FGFR3, and expression of HPV16 E6/E7, supporting a causal role of HPV16 in these carcinomas. This evidence concerns the gene FGFR3 and carcinoma.