As displayed in Figure 2A,B, the uptake of methionine was significantly decreased in 786-O and 769-P cells after being incubated with 50 μmol/L methionine with JPH203 (1 and 5 μmol/L) at 37 °C for 3 min, suggesting that LAT1 take charge of uptake of methionine in RCC cells. This evidence concerns the gene SLC7A5 and renal cell adenocarcinoma.