Moreover, whole-transcriptome profiling allowed high-dimensional clustering of sarcomas, showing that most fusion genes are associated with a characteristic transcriptomic profile, and that some sarcomas with differing fusion transcripts can be grouped into transcriptomically homogeneous entities, such as CIC-fused sarcomas which comprise CIC-DUX4, CIC-FOX4, and CIC-NUTM1 sarcomas. Here, DUX4 is linked to sarcoma.