CD8A and neoplasm: In particular, T cells predominate the core of a tumour and extend beyond his invasive edge, with CD8+ T cells exerting direct cytotoxic activity and CD4+ T cells mediating antitumoral responses through the secretion of a high amount of proinflammatory cytokines (IL-2, TNF-α, INF-γ), which in turn activate macrophages and NK cells [20,21,22].