Specifically, for GBM, the following genes had an HR < 1: CHRNA7, GABRA3, GRIA3, and HTR5A; whereas the following genes had an HR > 1: ADRA1B, ADRA2A, ADRA2C, CHRM3, CHRM4, CHRNA5, CHRNB2, DRD1, GABRA1, GABRA2, GABRA4, GABRB2, GABRD, GABRG3, GRIN1, GRIN3A, GRM5, GRM7, HTR1E, and HTR3B. The gene discussed is CHRM4; the disease is glioblastoma.