Here, we performed an initial screen of 47 lung adenocarcinoma (LUAD) cell lines to identify protein signatures related to KEAP1 mutational status and activated NRF2, the results of which revealed the kynurenine-metabolizing enzyme kynureninase (KYNU) as a top differential overexpressed protein associated with activated NRF2. This evidence concerns the gene NFE2L2 and lung adenocarcinoma.