NFE2L2 and lung adenocarcinoma: Activation of the nuclear factor erythroid 2-related factor 2 (NRF2) pathway, either through gain-of-function mutation or loss-of-function of its suppressor, Kelch-like ECH-associated protein 1 (KEAP1), is one of the most dysregulated pathways in lung adenocarcinoma (LUAD) [1,2].