CD8A and neoplasm: Elevated KYNU protein expression was significantly positively associated with high numbers of CD8+ tumor infiltrating lymphocytes (TILs) (stratified by median, two-sided χ2 test for Trend p = 0.007), as well as PD-L1 cell positivity (stratified by median, two-sided χ2 test for Trend p = 0.02) (Figure 3D).