MED19 and bladder transitional cell carcinoma: MED19, a component of the mediator complex that regulates the transcription of RNA polymerases, was found via IHC to be overexpressed in human BLCA compared to normal tissues, and its knockdown in the T24 and 5637 bladder cell lines resulted in cell-cycle arrest at the G0/G1 checkpoint, along with attenuation of cell growth [55].