PTGS2 and cancer: β-adrenergic signaling has specifically been shown to increase macrophage recruitment to the TME, which subsequently stimulates the release of various factors that promote cancer progression, including TGF-β, VEGF, interleukin-6, matrix metalloproteinase-9 (MMP-9), and prostaglandin-endoperoxide synthase 2 (PTGS2) [37].