The most common findings of immunosuppression may be due to the positive correlation of SNS signatures with PD-1 or PD-L1 expression, with significant associations in nine cancer types including BRCA, ESCA, LGG, LIHC, lung adenocarcinoma (LUAD), PAAD, PRAD, THCA, and thymoma (THYM). The gene discussed is CD274; the disease is lung adenocarcinoma.