The TNG signatures were significantly and positively correlated with angiogenesis in 18 (72%) of the tested cancer types, with the strongest correlation found in pancreatic adenocarcinoma (PAAD) (r = 0.59, p < 1.0 × 10−15), and also associated with TGF-β pathway activation in 17 (68%) tested cancer types, with the strongest correlation found in liver hepatocellular carcinoma (LIHC) (r = 0.57, p < 1.0 × 10−15). The gene discussed is TGFB1; the disease is cancer.