Ariffin et al. evaluated the levels of cytokines produced by helper T lymphocytes (Th) such as Th1 (IL-2, TNFα, IFNγ), Th2 (IL-4, IL-6, IL-10), and Th17 (IL-17A) in 87 asymptomatic ALL survivors. This evidence concerns the gene IL4 and acute lymphoblastic leukemia.