The Immunoscore® (IS®) represents a classification system that incorporates the number, type, and distribution of immune cells [8,9,10] using the CD3+ and CD8+ cell densities in the center of the tumor and the invasive margin of localized colon cancer patients, with higher scores indicative of infiltration by more significant numbers of total T cells (CD3+) and cytotoxic T cells (CD8+) in both the tumor core and margins. This evidence concerns the gene CD8A and colonic neoplasm.