Based on this work, we found that NEDD9 restrains ATM-CHK2 signaling in NSCLC cells, with low NEDD9 levels associated with enhanced DNA damage, the upregulation of the ATM-CHK2 pathway, a shift towards a more mesenchymal phenotype, and an elevated sensitivity to UV irradiation. This evidence concerns the gene NEDD9 and non-small cell lung carcinoma.