The mechanistic analysis of human and murine NSCLC cell lines demonstrated that UV irradiation for 2 and 6 h of SCR and siNEDD9-depleted cells resulted in even greater ERCC4 activation upon NEDD9 depletion in A549 and H460 cell lines (Figure 4A and Figure S4A) and significant activation of ATM-CHK2 signaling axis in both SCR and siNEDD9-treated cells versus the SCR non-irradiated control in four out of five cell lines (Figure 4B and Figure S4B). This evidence concerns the gene CHEK2 and non-small cell lung carcinoma.