Recently, Gay et al. described four SCLC subtypes characterized by the differential expression of three transcription factors, ASCL1, NEUROD1, and POU2F3, or low expression of all three with an inflamed gene signature (SCLC-A, n, P and I, respectively) with distinct response to systemic treatment [62,63]. The gene discussed is NEUROD1; the disease is small cell lung carcinoma.