Recently, Gay et al. described four SCLC subtypes characterized by the differential expression of three transcription factors, ASCL1, NEUROD1, and POU2F3, or low expression of all three with an inflamed gene signature (SCLC-A, n, P and I, respectively) with distinct response to systemic treatment [62,63]. Here, ASCL1 is linked to small cell lung carcinoma.