The main affected genes are RASSF1A (Ras association domain family 1 isoform A), involved in cellular cycle and apoptosis; HIC-1 (hyper-methylated in cancer), a TP53 pathway effector; APC (Adenomatous polyposis coli), tumour suppressor gene responsible for familiar adenomatous polyposis; CDKN2A, suppressor gene encoding p16; MGMT (O-6-Methylguanine-DNA Methyltransferase), involved in DNA repair and likely with predictive value of response to alkylating agents such as temozolomide [45]; MLH1 (MutL homology 1), related to microsatellites instability; and VHL [43,46,47]. The gene discussed is CDKN2A; the disease is cancer.