TRIM63 and cancer: Similarly, a clinical trial reports that 10-week concurrent resistance (knee extension, leg press, lateral pull-down, chest-press, back extension and sit-ups) and endurance (ergometer cycling) training in cancer patients treated with chemotherapy can prevent cancer- and chemotherapy-induced disruptions in molecular signalling cascades associated with the ubiquitin proteasome system (e.g., Atrogin-1 and Murf-1) and protein synthesis (e.g., mTOR) [78].