Furthermore, voluntary wheel running (for ~2.5 weeks) counteracts cancer-induced protein degradation through suppressing both the induction of ubiquitin ligases (Atrogin1, also known as Fbxo32; and Murf1, also known as Trim63) and the protein expression of autophagic markers (LC3bII/LC3bI ratio and p62/Gapdh ratio) in female C26 tumour-bearing mice [32]. The gene discussed is TRIM63; the disease is neoplasm.