Specifically, the voluntary wheel running attenuated CC-induced mitochondrial abnormalities in tumour-bearing C26 mice attenuating: (i) decreased expression levels of mitochondrial-related proteins (OXPHOS subunit proteins and PGC-1α); (ii) decreased mitochondrial enzyme activity (citrate synthase and cytochrome c oxidase); (iii) decreased expression levels of mitochondrial fusion and fission proteins (Mfn2 and Drp1); (iv) increased mitochondrial oxidative stress; and (v) increased appearance of damaged mitochondria with disrupted cristae structure [109]. This evidence concerns the gene PPARGC1A and neoplasm.