PROK2 and metastatic malignant neoplasm in the lymph nodes: Analysis of clinicopathological features relative to PTPRM and PROK2 immunohistochemical expression (Table 3) showed that PTPRM was positively correlated with the incidence of PC carcinoma and lymph node metastasis (p = 0.001 and p = 0.005, respectively) and showed a slight relation to advanced GC (p = 0.059).