Comparison of PC and SRC carcinomas with combined PC/SRC carcinoma showed that PTPRM, MMP3, AREG, SFRP2, and ITGB1BP1 were upregulated in PC carcinoma, whereas AREG, PROK2, ID1, CRDBBP, and IL1RL1 were upregulated in SRC carcinoma. The gene discussed is ITGB1BP1; the disease is pachyonychia congenita.