AKT1 and neoplasm: To interrogate intracellular signaling pathway(s) that are important downstream of HGFL-RON signaling in tumor cells that elicit macrophage migration, we repeated the migration assay using R7 cells with and without Akt inhibition (AKTi), ERK1/2 inhibition (MAPKi), Stat3 inhibition (STAT3i) or NFkB inhibition (NFKBi); these pathways are all known targets of HGFL-RON signaling [10].