We used nine driver genes identified in this study (TP53, ESR1, GATA3, KMT2C, NCOR1, AKT1, NF1, RIC8A, RB1) as well as additional genes frequently altered in breast cancer (PTEN, PIK3CA, BRCA1, BRCA2, ERBB2, EGFR). This evidence concerns the gene RB1 and breast carcinoma.