MST1 and neoplasm: Tumor cell proliferation (BrdU+ staining) was reduced in R7 shNT tumor-bearing HGFL−/− mice compared with R7 shNT tumor-bearing WT mice complemented by elevated cell death (TUNEL+ staining) as depicted in Figure 3C. These data demonstrate that even while tumor cell-produced HGFL is present, loss of physiologic HGFL reduces tumor cell proliferation and enhances cell death.