TP53 and cancer: Moreover, overexpression of miRNAs significantly enriched genes such as: cyclin-dependent kinase 6 (CDK6), cyclin-dependent kinase 4 (CDK4), N-acetyltransferase 1 (NAT1), interferon regulatory factor 2 (IRF2), SMAD family member 2 (SMAD2), and tumor protein 53 (TP53), among others, involved in 20 signaling pathways, including pathways in cancer, p53 signaling pathways, cell cycle, ErbB, Notch, MAPK, and mTOR (Figure 5, right panel).