Moreover, overexpression of miRNAs significantly enriched genes such as: cyclin-dependent kinase 6 (CDK6), cyclin-dependent kinase 4 (CDK4), N-acetyltransferase 1 (NAT1), interferon regulatory factor 2 (IRF2), SMAD family member 2 (SMAD2), and tumor protein 53 (TP53), among others, involved in 20 signaling pathways, including pathways in cancer, p53 signaling pathways, cell cycle, ErbB, Notch, MAPK, and mTOR (Figure 5, right panel). Here, SMAD2 is linked to cancer.