Of note, ARCH is characterized by the presence of somatic mutations in genes that are also frequently mutated in SM (e.g., ASXL1, DNMT3A, EZH2, RUNX1, SF3B1, SRSF2 and TET2) and other myeloid neoplasms [92,173,174]. Here, EZH2 is linked to myeloid neoplasm.