Some of these ARCH-related genetic mutations that are frequently reported in AdvSM cases have been confirmed to be directly associated with the development of haematopoietic neoplasms and are considered clonal haematopoiesis of oncogenic potential (CHOP) mutations [175] (e.g., SRSF2 [11], ASXL1 [11], DNMT3A [80], RUNX1 [11], EZH2 [13], CBL [90]). The gene discussed is SRSF2; the disease is hematopoietic and lymphoid cell neoplasm.