Overall, these studies found a total of 30 different genes to be mutated in SM (Table 2 and Table S1), from which 11 (i.e., ASXL1, CBL, DNMT3A, EZH2, JAK2, KRAS, NRAS, RUNX1, SF3B1, SRSF2, TET2) are recurrently mutated genes in several SM cohorts (Table 3, Table 4 and Table 5). Here, DNMT3A is linked to systemic mastocytosis.