Of note, ARCH is characterized by the presence of somatic mutations in genes that are also frequently mutated in SM (e.g., ASXL1, DNMT3A, EZH2, RUNX1, SF3B1, SRSF2 and TET2) and other myeloid neoplasms [92,173,174]. The gene discussed is SRSF2; the disease is myeloid neoplasm.