PIK3CA and cancer: In a wide variety of cancers, the deregulation and activation of PI3K/AKT and YAP/TAZ signaling is nowadays considered as a key event supporting mechano-transduction (shear forces, elasticity, and tissue stretching) [3,6], metabolism, cell cycle progression, survival, epithelial-mesenchymal transition (EMT), metastasis, and drug resistance (including immunotherapy) [3,4,5,7,8,9,10,11].