In ETP-ALL, the presence of different gene-mutations involving hematopoietic development (IKZF1, ETV6, RUNX1, GATA3, and EP300), MAPK and cytokine receptor signaling (FLT3, NRAS, KRAS, IL7R, JAK1, JAK3, PTPN11, NF1, and SH2B3), and chromatin-modifying genes (EED, EZH2, SUZ12, and SETD2) have been demonstrated [2]. This evidence concerns the gene EZH2 and acute lymphoblastic leukemia.