CTSB and cancer: They fused two well-characterized cancer antigens, namely, the melanoma-specific MAGE-A1 (hydrophilic) and the esophageal squamous cell carcinoma-specific NY-ESO-1 (hydrophobic), with a dipeptide linker substrate of cathepsin B. These conjugates self-assembled and were incorporated into a lipid bilayer derived from erythrocyte membranes with the addition of mannose residues.