Drug and siRNA release were obtained via peptide cleavage by MMP2; in addition, photothermal treatment was achieved by laser NIR irradiation of the tumor mass, resulting in an almost complete tumor regression after 36 days of treatment, with 60% of the animals still alive at the end of the experiment (day 125), compared with <35% of those treated with VEGF-siRNA+AS1411 nanocages not loaded with doxorubicin. The gene discussed is VEGFA; the disease is neoplasm.