Comparison of the genetic profiles of ETP-ALL and T/M MPAL with non-immature T-ALL leukemias in pediatric cases has shown that the core TF driving T-ALL (TAL1, TAL2, TLX1, TLX3, LMO1, LMO2, NKX2- 1, HOXA10, and LYL1) is less frequently altered in T/M MPAL and ETP-ALL. This evidence concerns the gene LYL1 and acute lymphoblastic leukemia.