Overexpression of the BCL11B gene due to different structural abnormalities including translocations (i.e., t(2;14)(q22.3;q32), t(6;14)(q25.3;q32), hijacking super-enhancers, and other fusion genes has been very recently described as present in one third of ETP-ALL and T/myeloid mixed phenotype acute leukemia (T/M MPAL) cases with a very distinct expression profile [46,47]. Here, BCL11B is linked to acute lymphoblastic leukemia.