TF and acute lymphoblastic leukemia: Subsequent studies used the same experimental procedure; (1) identification of a core sequence by CHIP-seq in T-ALL cell lines; (2) identification of epigenetic marks supporting transcriptional activity in the region and the transcriptional complex; and (3) validation of the alteration in a large cohort of pediatric T-ALL cases revealed a C-to-T single nucleotide transition occurring as a somatic mutation in the non-coding sequence 4 kb upstream of the transcriptional start site of the LMO1 TF.