First of all, in line with previously published data showing higher SSTR5 expression level in corticotroph tumor tissues bearing USP8 mutations [4,13], we also observed SSTR5 upregulation in primary cultured cells from USP8 wild-type ACTH-secreting PitNETs upon transient transfection with S718del USP8 mutant. The gene discussed is USP8; the disease is neoplasm.