Contrary to NEMO ablation, LPC-specific knockout of the upstream kinase TAK1 was shown to induce CLD and hepatocarcinogenesis through autophagy impairment by modulating AMPK and mTORC1 activation [13,14], which were not affected in NEMO-deficient hepatocytes. This evidence concerns the gene IKBKG and congenital secretory chloride diarrhea 1.