Nevertheless, determination of serum ALT levels (Figure 4B) and liver immunohistochemical analyses in livers of 8-week-old mice revealed that systemic or LPC-specific expression of p62ΔEx2-5 did not significantly alter liver injury or other CLD indicators, such as compensatory proliferation, inflammation and fibrosis, in NEMOLPC-KO mice (Figure 4C,D). Here, GPT is linked to congenital secretory chloride diarrhea 1.