Interestingly, analysis of the expression of two HCC diagnostic markers, namely α-fetoprotein (Afp) and glypican-3 (Gpc3) [56], showed that these two p62/Nrf2high tumors expressed very low Gpc3 levels, suggesting that p62/Nrf2 activation could define specific types of liver tumors. This evidence concerns the gene AFP and hepatocellular carcinoma.