Altogether, these data show that p62ΔEx2-5 mice do not develop obesity and fatty liver as p62KO mice do, supporting the dependence of this phenotype on p62/ERK inhibitory interaction [36], which is expected to remain unaffected in the p62ΔEx2-5 mutant. This evidence concerns the gene SQSTM1 and obesity due to melanocortin 4 receptor deficiency.