CD274 and neoplasm: Lastly, the variables significantly associated to PFS were setting of treatment (p = 0.016), type of treatment (p = 0.031), tumor burden (p = 0.003), presence of liver metastases (p = 0.002), PD-L1 staining (p < 0.001) and miR-625-5p class (p = 0.005) (Table S3).