In addition to its previously described functions, TP53 influences the induction of interferon-α and -β [104,105,106]; other proinflammatory cytokines (e.g., IL-1, IL-6, IL-12 and TNF) production [107,108] and immune checkpoint regulation; tumor cell TP53-dependent PD-1 and PD-L1 upregulation are observed as a response to DNA damage and other genotoxic stress [109,110,111]. Here, TP53 is linked to neoplasm.