During this study period, there were 1987 patients who had FISH for MET/CEP7 tested on the first diagnostic specimen of lung adenocarcinoma in our institution, including 112 (5.6%) patients with MET/CEP ratio ≥ 1.8 (MET-amp), 146 (7.3%) with polysomy 7, and 1729 (87%) with a MET-neg FISH results.9 Among the 258 patients with MET-amp or polysomy 7, 206 (88 with MET-amp and 118 with polysomy 7) had materials available for IHC. This evidence concerns the gene MET and lung adenocarcinoma.