PTK2 and hepatocellular carcinoma: Based on experiments with Huh7 cells, activating the FAK/AKT signaling pathway through integrin β4 was suggested to promote hepatocellular carcinoma metastasis [13], whereas the association between integrin β1-FAK-AKT and proliferation, migration, and invasion of hepatoma BEL-7402 cells was assumed by others [14].