Enhanced integrin α2 and β1 expression, induced by IGF1 (p-values ** 0.0040, ** 0.0028, respectively), was prevented by pre-treating the tumor cells with the specific AKT inhibitor MK-2206 (Figure 8B) (p-values ** 0.0029, * 0.0379,** 0.0035, * 0.0360, * 0.0414, ** 0.0012, respectively). This evidence concerns the gene IGF1 and neoplasm.