The effects are evaluated directly on HRS tumor cells and usually include tumor growth, migration, apoptosis, drug resistance, autophagy, immunosuppressive activity (such as the expression or secretion of immune suppressive molecules, like PDL-1, IL-10, IL-13) or modulation of key molecules (such as CD30, needed for BV efficacy), etc. (Figure 2). The gene discussed is IL13; the disease is neoplasm.