The HER-2-targeted nanobody 11A4 was used to achieve improved and selective uptake of polymeric NPs in HER-2+ BC cells SKBR-3 as compared to HER-2- MDA.MB.231 cells [84], while the sdAb C7b conjugated to silica NPs has been used to delivery drugs, imaging and theranostic agents [81]. Here, ERBB2 is linked to breast cancer.