Other examples of polymeric NPs exploited a covalent conjugation with TZ to specifically interact with the HER-2 receptor in HER-2+ BC [69,70,71], while Dominguez-Ríos et al. proposed a solution based on an HER-2-targeted PLGA nanoplatform covalently biofunctionalized with TZ for HER-2+ ovarian cancer [72]. Here, ERBB2 is linked to breast cancer.