Ma and coworkers designed and explored in vitro the potential of SKBR-3 cells with a tetrahedral framework of nucleic acids decorated with an anti-HER-2 aptamer, and showed that the construct is able to specifically target HER-2+ BC in SKBR-3 cells and induce lysosomal degradation of HER-2 [95]. This evidence concerns the gene ERBB2 and breast cancer.