FOXN1 and neoplasm: In vivo experiments with CD1-FOXn1/nu SK-OV-3 bearing mice showed that by PEGylating DAPRins, their biodistribution and a high tumor-blood ratio but were affected by a rapid clearance, while PEGylated DAPRins had much slower clearance that, on one hand, further increased tumor accumulation, but on the other hand decreased the tumor-blood ratio [102].