Using bioinformatic tools to find common putatively actionable alterations in a set of 33 types of cancer (including GBMs), it was found that across the entire data set, CDKN2A deletions (13%), PIK3CA mutations (12%), MYC amplifications (8%), and K-RAS mutations (7%) were the most common [64,65]. The gene discussed is MYC; the disease is cancer.