FERMT3 and central nervous system cancer: Regarding integrin receptor signaling, it could be shown that the adaptor protein and regulator of integrin function, kindlin-3 (FERMT3), regulates glioma cell activity through integrin-mediated Wnt/β-catenin signaling, suggesting FERMT3 activates integrin activity in high-grade gliomas to enhance TMZ chemoresistance [167].