The use of MDM2 (murine double minute 2) and MDMX (murine double minute X) antagonists, for example, has shown to be an effective way to allow p53 reactivation in p53wt tumors, to induce apoptosis, reduce tumor growth, and to sensitize GBM cells to radiation and TMZ [199,200,201,202,203,204,205,206]. This evidence concerns the gene TP53 and glioblastoma.