IL6 and neoplasm: These include a myriad of cell types (tumour cells, cancer-associated fibroblasts, macrophages, pancreatic stellate cells, and immune cells), their products (for example interleukin-1, interleukin-6, and transforming growth factor-β), and a network of blood vessels in a rich extracellular matrix (including collagen, fibronectin, and hyaluronan) which accounts for 90% of the total tumour volume [4,14,15].