PI3KCA signaling was downstream of FGFR1, and therefore PI3KCA-mutated cells showed reduced sensitivity to the FGFR1 inhibitor ponatinib when compared to wild-type PI3KCA cells in both breast and lung cancer cell lines, as observed in the database from DepMAP (Figure 2G,H). Here, FGFR1 is linked to lung carcinoma.