CD28 and adult T-cell leukemia/lymphoma: The following loci where copy number alterations (CNAs) frequently occur in the genome of patients with ATLL, and the genes presumed to be responsible for ATLL, have been reported: gains of 1p36 (SKI), 1q, 2q33.2 (CD28), 3, 6p25.3 (IRF4), 7p, 7q, 8q, and 14q32 (BCL11B), and losses of 1p13 (CD58), 6p21 (HLA-A), 6p22 (HLA-B, ATXN1), 6q14 (SYNCRIP), 9p21 (CDKN2A), 13q32 (GPR183), 14q31 (NRXN3), and 17p13 (TP53) [14,17,19,56,57,58,59,60].