Today, three genetic mouse models mimic AITL cancer in terms of clinical, pathological, histological, transcriptional, genetic and immunophenotypic features: (1) two mouse models are based on the knockout of Tet2 and overexpression of RhoAG17V, (2) another model was generated by overexpression in the T-cell lineage of a key enzyme in glycolysis, GAPDH. Here, GAPDH is linked to angioimmunoblastic T-cell lymphoma.