KRAS and colorectal carcinoma: According to the transcriptional subtypes of BRAF-MTV600E CRC, the BM1 subtype was associated with a poorer prognosis, which is characterized by KRAS/AKT pathway activation, EMT that mediates chemotherapy resistance, and increased immune reactivity, whereas BM2 shows the deregulation of the cell-cycle checkpoints and was associated with better prognosis [18,24].