Therapeutic IL-17 targeting showed improvements in three different ALD mouse models: (1) an intragastric ethanol feeding model that recapitulated alcoholic steatohepatitis and fibrosis; (2) a chemical carcinogen diethylnitrosamine (DEN) + alcohol model that mimicked liver cancer associated with alcohol misuse; and (3) a chronic feeding with weekly binge drinking model that mimicked alcoholic hepatitis and steatohepatitis (Figure 2). Here, IL17A is linked to alcoholic hepatitis.