We also performed a cytotoxicity assay with the SHP-2 inhibitor SHP099 [23] and found that the sensitivity of SHP-2 (WT)-expressing cells to this agent was similar to that of parental cells, whereas SHP-2 (G503V)-expressing cells as well as tumor-derived A-1 cells were less sensitive to SHP099 (Figure 4D). The gene discussed is PTPN11; the disease is neoplasm.