In addition to these functions, it has been consistently reported that the HNF1B locus plays a key role in modulating tumorigenesis in solid [79] and hematological cancers [80], and that its methylation or mRNA expression levels can be used for patient stratification [81] and prediction of disease outcome [82]. The gene discussed is HNF1B; the disease is hematopoietic and lymphoid cell neoplasm.