In conclusion, our study indicates that T2D-related variants within the HNF1B, FTO, and JAZF1 genes influence the risk of PCa likely through the modulation of diabetogenic pathways, and suggests, for the first time, an association of SNPs within the NOTCH2 and RBMS1 loci that need to be validated in independent cohorts. This evidence concerns the gene HNF1B and type 2 diabetes mellitus.