IGF1 and Insulin resistance: Even though there is not much evidence about the functional role of the JAZF1rs10486567 SNP in PCa, it has been demonstrated that the deletion of the JAZF1 locus is associated with reduced levels of IGF-1 and insulin resistance in mice [95], which suggests that the presence of functional polymorphisms within this locus might act to promote PCa development through diabetogenic mechanisms.