This study also suggests that the effect of the HFN1B SNPs on PCa risk might be mediated by not only the ST1A1 protein, but also HFN1B mRNA expression levels, whereas the effect of the FTO, JAZF1, NOTCH2, and RBMS1 SNPs on PCa risk seem to be involved in the regulation of mRNA expression levels of their respective genes. The gene discussed is FTO; the disease is posterior cortical atrophy.