These findings, together with our functional results reporting that carriers of the HNF1Brs7501939T and HNF1Brs757210T alleles showed decreased levels of SULT1A1 protein (also known as ST1A1), suggest that the effect of the HFN1B locus on PCa risk might be mediated through the regulation of SULT1A1 expression levels. Here, SULT1A1 is linked to posterior cortical atrophy.